7OFL

Crystal structure of the sesquiterpene synthase Copu9 from coniophora puteana in complex with alendronate

Summary for 7OFL

• Entry DOI: 10.2210/pdb7ofl/pdb
• Descriptor: Terpene synthase, 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: terpene synthase, sesquiterpene, cyclase, terpenoid, lyase
• Biological source: Coniophora puteana (strain RWD-64-598) (Brown rot fungus)
• Total number of polymer chains: 2
• Total formula weight: 87119.49

Authors

Dimos, N.,Loll, B. (deposition date: 2021-05-05, release date: 2022-03-16, Last modification date: 2024-01-31)

Primary citation

Ringel, M.,Dimos, N.,Himpich, S.,Haack, M.,Huber, C.,Eisenreich, W.,Schenk, G.,Loll, B.,Bruck, T.
Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of delta-cadinol.
Microb Cell Fact, 21:64-64, 2022

PubMed Abstract: Terpene synthases are versatile catalysts in all domains of life, catalyzing the formation of an enormous variety of different terpenoid secondary metabolites. Due to their diverse bioactive properties, terpenoids are of great interest as innovative ingredients in pharmaceutical and cosmetic applications. Recent advances in genome sequencing have led to the discovery of numerous terpene synthases, in particular in Basidiomycota like the wood rotting fungus Coniophora puteana, which further enhances the scope for the manufacture of terpenes for industrial purposes.

PubMed: 35440053
DOI: 10.1186/s12934-022-01791-8

Experimental method

X-RAY DIFFRACTION (1.83 Å)