7OFB

Keap1 kelch domain bound to a small molecule fragment

Summary for 7OFB

Entry DOI	10.2210/pdb7ofb/pdb
Descriptor	Kelch-like ECH-associated protein 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	keap1, nrf2, oxidative stress, small molecule complex, maybridge, peptide binding protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	34206.49
Authors	Narayanan, D.,Bach, A.,Gajhede, M. (deposition date: 2021-05-04, release date: 2022-11-02, Last modification date: 2024-01-31)
Primary citation	Narayanan, D.,Tran, K.T.,Pallesen, J.S.,Solbak, S.M.O.,Qin, Y.,Mukminova, E.,Luchini, M.,Vasilyeva, K.O.,Gonzalez Chichon, D.,Goutsiou, G.,Poulsen, C.,Haapanen, N.,Popowicz, G.M.,Sattler, M.,Olagnier, D.,Gajhede, M.,Bach, A. Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65:14481-14526, 2022 Cited by PubMed: 36263945 DOI: 10.1021/acs.jmedchem.2c00830 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation