7OER
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-(2,2-diphenylethyl)-1,5-dimethyl-N-(2-(methylamino)-2-oxoethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
This is a non-PDB format compatible entry.
Summary for 7OER
Entry DOI | 10.2210/pdb7oer/pdb |
Related | 7OE0 7OEP |
Descriptor | Bromodomain-containing protein 2, N-(2,2-diphenylethyl)-1,5-dimethyl-N-[2-(methylamino)-2-oxidanylidene-ethyl]-6-oxidanylidene-pyridine-3-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13912.03 |
Authors | Chung, C. (deposition date: 2021-05-03, release date: 2021-07-21, Last modification date: 2021-08-25) |
Primary citation | Rianjongdee, F.,Atkinson, S.J.,Chung, C.W.,Grandi, P.,Gray, J.R.J.,Kaushansky, L.J.,Medeiros, P.,Messenger, C.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rioja, I.,Satz, A.L.,Taylor, S.,Wall, I.D.,Watson, R.J.,Yao, G.,Demont, E.H. Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit. J.Med.Chem., 64:10806-10833, 2021 Cited by PubMed: 34251219DOI: 10.1021/acs.jmedchem.1c00412 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.602 Å) |
Structure validation
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