7OEO

C-TERMINAL BROMODOMAIN OF HUMAN BRD4 N-(2,2-diphenylethyl)-4-methoxy-3,5-dimethyl-N-(2-(methylamino)-2-oxoethyl)benzamide

This is a non-PDB format compatible entry.

Summary for 7OEO

• Entry DOI: 10.2210/pdb7oeo/pdb
• Descriptor: Bromodomain-containing protein 4, N-(2,2-diphenylethyl)-4-methoxy-3,5-dimethyl-N-[2-(methylamino)-2-oxidanylidene-ethyl]benzamide (3 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, nuclear protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14067.25

Authors

Chung, C. (deposition date: 2021-05-03, release date: 2021-07-21, Last modification date: 2024-05-01)

• Primary citation: Rianjongdee, F.,Atkinson, S.J.,Chung, C.W.,Grandi, P.,Gray, J.R.J.,Kaushansky, L.J.,Medeiros, P.,Messenger, C.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rioja, I.,Satz, A.L.,Taylor, S.,Wall, I.D.,Watson, R.J.,Yao, G.,Demont, E.H.; Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.; J.Med.Chem., 64:10806-10833, 2021; PubMed: 34251219; DOI: 10.1021/acs.jmedchem.1c00412

Experimental method

X-RAY DIFFRACTION (1.51 Å)