7OEM

Crystal structure of the human METTL3-METTL14 complex with compound UOZ120

Summary for 7OEM

Entry DOI	10.2210/pdb7oem/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	mettl3, inhibitor, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62510.40
Authors	Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-05-03, release date: 2021-10-20, Last modification date: 2024-11-13)
Primary citation	Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation