7OEI

Crystal structure of the human METTL3-METTL14 complex with compound UOZ083

Summary for 7OEI

• Entry DOI: 10.2210/pdb7oei/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (3~{R})-3-[[5-[(4,4-dimethylpiperidin-1-yl)methyl]-1~{H}-benzimidazol-2-yl]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-ol, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62364.08

Authors

Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-05-03, release date: 2021-10-20, Last modification date: 2024-02-07)

• Primary citation: Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A.; Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3; Acs Bio Med Chem Au, 2023; DOI: 10.1021/acsbiomedchemau.3c00023

Experimental method

X-RAY DIFFRACTION (2.48 Å)