7OE8

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N5-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(1H-indol-4-yl)-N7-methyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

Summary for 7OE8

• Entry DOI: 10.2210/pdb7oe8/pdb
• Descriptor: Bromodomain-containing protein 2, 1,2-ETHANEDIOL, (3S)-3-(1H-indol-4-yl)-N7-methyl-N5-[(1R,5S)-3-oxabicyclo[3.1.0]hexan-6-yl]-2,3-dihydro-1-benzofuran-5,7-dicarboxamide, ... (4 entities in total)
• Functional Keywords: inhibitor, bromodomain, nuclear protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13974.06

Authors

Chung, C. (deposition date: 2021-05-02, release date: 2021-07-28, Last modification date: 2024-05-01)

• Primary citation: Lucas, S.C.C.,Atkinson, S.J.,Chung, C.W.,Davis, R.,Gordon, L.,Grandi, P.,Gray, J.J.R.,Grimes, T.,Phillipou, A.,Preston, A.G.,Prinjha, R.K.,Rioja, I.,Taylor, S.,Tomkinson, N.C.O.,Wall, I.,Watson, R.J.,Woolven, J.,Demont, E.H.; Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.; J.Med.Chem., 64:10711-10741, 2021; PubMed: 34260229; DOI: 10.1021/acs.jmedchem.1c00344

Experimental method

X-RAY DIFFRACTION (1.301 Å)