7OBU

Crystal structure of holo-F210W mutant of Hydroxy ketone aldolase (SwHKA) from Sphingomonas wittichii RW1, with the active site in the resting and the active state

Summary for 7OBU

Entry DOI	10.2210/pdb7obu/pdb
Related	6R62 7NNK 7NR1 7NUJ 7O5I 7O5R 7O5V 7O5W 7O87 7O9R
Descriptor	HpcH/HpaI aldolase, MAGNESIUM ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	class ii pyruvate aldolase, metal dependent, aldol reaction, hydroxypyruvate, pyruvate, aldolase, carbon bond formation, holo, lyase
Biological source	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Total number of polymer chains	2
Total formula weight	53877.99
Authors	Laustsen, J.,Justo, I.,Marsden, S.R.,Hanefeld, U.,Bento, I. (deposition date: 2021-04-23, release date: 2022-10-26, Last modification date: 2024-01-31)
Primary citation	Marsden, S.R.,Wijma, H.J.,Mohr, M.K.F.,Justo, I.,Hagedoorn, P.L.,Laustsen, J.,Jeffries, C.M.,Svergun, D.,Mestrom, L.,McMillan, D.G.G.,Bento, I.,Hanefeld, U. Substrate Induced Movement of the Metal Cofactor between Active and Resting State. Angew.Chem.Int.Ed.Engl., 61:e202213338-e202213338, 2022 Cited by PubMed: 36214476 DOI: 10.1002/anie.202213338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation