7OAI

Crystal structure of pseudokinase CASK in complex with PFE-PKIS12

7OAI の概要

• エントリーDOI: 10.2210/pdb7oai/pdb
• 分子名称: Peripheral plasma membrane protein CASK, 4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: pseudokinase, kinase, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161230.72

構造登録者

Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2021-04-19, 公開日: 2021-05-19, 最終更新日: 2024-01-31)

• 主引用文献: Russ, N.,Schroder, M.,Berger, B.T.,Mandel, S.,Aydogan, Y.,Mauer, S.,Pohl, C.,Drewry, D.H.,Chaikuad, A.,Muller, S.,Knapp, S.; Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.; J.Med.Chem., 64:14358-14376, 2021; PubMed: 34543009; DOI: 10.1021/acs.jmedchem.1c00845

実験手法

X-RAY DIFFRACTION (2.3 Å)