7O4W

Crystal structure of diphtheria toxin mutant CRM197 with a disulphide bond replaced by a Cys-Acetone-Cys bridge

Summary for 7O4W

Entry DOI	10.2210/pdb7o4w/pdb
Descriptor	Diphtheria toxin, 1-hydroxypropan-2-one, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	diphtheria toxin, mutant, disulphide bridge, modified disulphide bridge, acetone., toxin
Biological source	Corynebacterium diphtheriae
Total number of polymer chains	1
Total formula weight	59103.09
Authors	Veggi, D.,Dello Iacono, L. (deposition date: 2021-04-07, release date: 2022-04-06, Last modification date: 2024-01-31)
Primary citation	Carboni, F.,Kitowski, A.,Sorieul, C.,Veggi, D.,Marques, M.C.,Oldrini, D.,Balducci, E.,Brogioni, B.,Del Bino, L.,Corrado, A.,Angiolini, F.,Dello Iacono, L.,Margarit, I.,Romano, M.R.,Bernardes, G.J.L.,Adamo, R. Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates. Chem Sci, 13:2440-2449, 2022 Cited by PubMed: 35310500 DOI: 10.1039/d1sc01928g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03002061079 Å)

Structure validation