7O4W

Crystal structure of diphtheria toxin mutant CRM197 with a disulphide bond replaced by a Cys-Acetone-Cys bridge

7O4W の概要

• エントリーDOI: 10.2210/pdb7o4w/pdb
• 分子名称: Diphtheria toxin, 1-hydroxypropan-2-one, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: diphtheria toxin, mutant, disulphide bridge, modified disulphide bridge, acetone., toxin
• 由来する生物種: Corynebacterium diphtheriae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59103.09

構造登録者

Veggi, D.,Dello Iacono, L. (登録日: 2021-04-07, 公開日: 2022-04-06, 最終更新日: 2024-01-31)

• 主引用文献: Carboni, F.,Kitowski, A.,Sorieul, C.,Veggi, D.,Marques, M.C.,Oldrini, D.,Balducci, E.,Brogioni, B.,Del Bino, L.,Corrado, A.,Angiolini, F.,Dello Iacono, L.,Margarit, I.,Romano, M.R.,Bernardes, G.J.L.,Adamo, R.; Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates.; Chem Sci, 13:2440-2449, 2022; PubMed: 35310500; DOI: 10.1039/d1sc01928g

実験手法

X-RAY DIFFRACTION (2.03002061079 Å)