7O4D

QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline

7O4D の概要

• エントリーDOI: 10.2210/pdb7o4d/pdb
• 分子名称: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: inhibitors, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58530.49

構造登録者

Gould, N.L.,Scherer, G.R.,Carvalh, S.,Shurrush, K.,Edry, E.,Elkobi, A.,David, O.,Dym, O.,Albeck, S.,Peleg, Y.,Germain, N.,Babaev, I.,Sharir, H.,Lefker, B.,Subramanyam, C.,Barr, H.,Rosenblum, K. (登録日: 2021-04-06, 公開日: 2022-08-17, 最終更新日: 2024-02-28)

• 主引用文献: Gould, N.L.,Scherer, G.R.,Carvalho, S.,Shurrush, K.,Kayyal, H.,Edry, E.,Elkobi, A.,David, O.,Foqara, M.,Thakar, D.,Pavesi, T.,Sharma, V.,Walker, M.,Maitland, M.,Dym, O.,Albeck, S.,Peleg, Y.,Germain, N.,Babaev, I.,Sharir, H.,Lalzar, M.,Shklyar, B.,Hazut, N.,Khamaisy, M.,Levesque, M.,Lajoie, G.,Avoli, M.,Amitai, G.,Lefker, B.,Subramanyam, C.,Shilton, B.,Barr, H.,Rosenblum, K.; Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.; J.Clin.Invest., 133:-, 2023; PubMed: 37561584; DOI: 10.1172/JCI162120

実験手法

X-RAY DIFFRACTION (2.249 Å)