7O2X

Crystal structure of the human METTL3-METTL14 complex with compound T180

Summary for 7O2X

• Entry DOI: 10.2210/pdb7o2x/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, N-[(6-methylimidazo[1,2-a]pyridin-2-yl)methyl]-4-oxidanylidene-pyrido[1,2-a]pyrimidine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62157.71

Authors

Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-03-31, release date: 2021-04-07, Last modification date: 2024-01-31)

• Primary citation: Bedi, R.K.,Huang, D.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 complex with compound T180; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)