Summary for 7O18
Entry DOI | 10.2210/pdb7o18/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, (R)-4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15674.05 |
Authors | Chung, C. (deposition date: 2021-03-28, release date: 2021-10-13, Last modification date: 2024-05-01) |
Primary citation | Jones, K.L.,Beaumont, D.M.,Bernard, S.G.,Bit, R.A.,Campbell, S.P.,Chung, C.W.,Cutler, L.,Demont, E.H.,Dennis, K.,Gordon, L.,Gray, J.R.,Haase, M.V.,Lewis, A.J.,McCleary, S.,Mitchell, D.J.,Moore, S.M.,Parr, N.,Robb, O.J.,Smithers, N.,Soden, P.E.,Suckling, C.J.,Taylor, S.,Walker, A.L.,Watson, R.J.,Prinjha, R.K. Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression. J.Med.Chem., 64:12200-12227, 2021 Cited by PubMed: 34387088DOI: 10.1021/acs.jmedchem.1c00855 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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