7O0Q

Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066)

Summary for 7O0Q

• Entry DOI: 10.2210/pdb7o0q/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 3-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-8-[6-(methylamino)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-2-one, ... (6 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62312.29

Authors

Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2021-03-26, release date: 2021-09-15, Last modification date: 2024-01-31)

• Primary citation: Bedi, R.K.,Dolbois, A.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.49 Å)