7NZK
14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-121
Summary for 7NZK
Entry DOI | 10.2210/pdb7nzk/pdb |
Related | 6QHL |
Descriptor | 14-3-3 protein sigma, Transcription factor p65, 4-[(3~{R})-3-methoxypiperidin-1-yl]sulfonylbenzaldehyde, ... (4 entities in total) |
Functional Keywords | benzaldehyde, covalent fragment, p65, 1433, rela, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28254.69 |
Authors | Wolter, M.,Ottmann, C. (deposition date: 2021-03-24, release date: 2021-06-09, Last modification date: 2024-01-31) |
Primary citation | Wolter, M.,Valenti, D.,Cossar, P.J.,Hristeva, S.,Levy, L.M.,Genski, T.,Hoffmann, T.,Brunsveld, L.,Tzalis, D.,Ottmann, C. An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64:8423-8436, 2021 Cited by PubMed: 34076416DOI: 10.1021/acs.jmedchem.1c00401 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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