7NWU

Co-crystal structure of UPF3B-RRM-NOPS-L with UPF2-MIF4GIII

7NWU の概要

• エントリーDOI: 10.2210/pdb7nwu/pdb
• 分子名称: Regulator of nonsense transcripts 3B, Regulator of nonsense transcripts 2, PENTAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: nonsense mediated mrna decay neurological development x-linked intellectual disability up-frameshift proteins, rna binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 177442.41

構造登録者

Powers, K.T.,Bufton, J.C.,Szeto, J.A.,Schaffitzel, C. (登録日: 2021-03-17, 公開日: 2022-07-20, 最終更新日: 2024-01-31)

• 主引用文献: Bufton, J.C.,Powers, K.T.,Szeto, J.A.,Toelzer, C.,Berger, I.,Schaffitzel, C.; Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.; Nucleic Acids Res., 50:5934-5947, 2022; PubMed: 35640974; DOI: 10.1093/nar/gkac421

実験手法

X-RAY DIFFRACTION (2.6 Å)