7NUS
X-RAY STRUCTURE OF HDM2/CMR19 AT 1.45A: Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Summary for 7NUS
Entry DOI | 10.2210/pdb7nus/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, p53/MDM2 macrocyclic peptide inhibitor, SULFATE ION, ... (5 entities in total) |
Functional Keywords | peptidream, peptide macrocycle, ligase, ppi inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 39395.32 |
Authors | Kallen, J. (deposition date: 2021-03-13, release date: 2021-09-22, Last modification date: 2024-01-31) |
Primary citation | Schneider, A.F.L.,Kallen, J.,Ottl, J.,Reid, P.C.,Ripoche, S.,Ruetz, S.,Stachyra, T.M.,Hintermann, S.,Dumelin, C.E.,Hackenberger, C.P.R.,Marzinzik, A.L. Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. Rsc Chem Biol, 2:1661-1668, 2021 Cited by PubMed: 34977581DOI: 10.1039/d1cb00056j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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