7NRP
The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG
Summary for 7NRP
Entry DOI | 10.2210/pdb7nrp/pdb |
Descriptor | RNA (5'-R(*CP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*G)-3'), CACODYLATE ION, ... (4 entities in total) |
Functional Keywords | amide-lna, duplex, dna:rna, unmodified, dna-rna hybrid |
Biological source | synthetic construct More |
Total number of polymer chains | 2 |
Total formula weight | 6384.03 |
Authors | Thorpe, C.,Hardwick, J.,McDonough, M.A.,Hall, J.P.,Baker, Y.R.,El-Sagheer, A.H.,Brown, T. (deposition date: 2021-03-04, release date: 2022-06-22, Last modification date: 2024-01-31) |
Primary citation | Baker, Y.R.,Thorpe, C.,Chen, J.,Poller, L.M.,Cox, L.,Kumar, P.,Lim, W.F.,Lie, L.,McClorey, G.,Epple, S.,Singleton, D.,McDonough, M.A.,Hardwick, J.S.,Christensen, K.E.,Wood, M.J.A.,Hall, J.P.,El-Sagheer, A.H.,Brown, T. An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nat Commun, 13:4036-4036, 2022 Cited by PubMed: 35821218DOI: 10.1038/s41467-022-31636-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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