7NR4

X-RAY STRUCTURE OF PRMT6 IN COMPLEX WITH indazole type inhibitor

7NR4 の概要

• エントリーDOI: 10.2210/pdb7nr4/pdb
• 分子名称: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, (2~{S})-2-azanyl-~{N}-[3-[3-(dimethylsulfamoyl)phenyl]-2~{H}-indazol-5-yl]propanamide, ... (4 entities in total)
• 機能のキーワード: protein arginine methyl transferase 6, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171385.70

構造登録者

Steuber, H. (登録日: 2021-03-02, 公開日: 2021-04-07, 最終更新日: 2024-01-31)

• 主引用文献: Sutherland, M.,Li, A.,Kaghad, A.,Panagopoulos, D.,Li, F.,Szewczyk, M.,Smil, D.,Scholten, C.,Bouche, L.,Stellfeld, T.,Arrowsmith, C.H.,Barsyte, D.,Vedadi, M.,Hartung, I.V.,Steuber, H.,Britton, R.,Santhakumar, V.; Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.; Chemmedchem, 16:1116-1125, 2021; PubMed: 33513288; DOI: 10.1002/cmdc.202100018

実験手法

X-RAY DIFFRACTION (2.03 Å)