7NQI
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 2-benzyl-N-cyclopropyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)isonicotinamide
Summary for 7NQI
Entry DOI | 10.2210/pdb7nqi/pdb |
Related | 7NQ5 7NQ7 7NQ8 7NQ9 |
Descriptor | Bromodomain-containing protein 2, 2-benzyl-N-cyclopropyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)isonicotinamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13952.05 |
Authors | Chung, C.W. (deposition date: 2021-03-01, release date: 2021-03-24, Last modification date: 2021-04-07) |
Primary citation | Aylott, H.E.,Atkinson, S.J.,Bamborough, P.,Bassil, A.,Chung, C.W.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Hayhow, T.G.,Messenger, C.,Mitchell, D.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Seal, J.T.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J.Med.Chem., 64:3249-3281, 2021 Cited by PubMed: 33662213DOI: 10.1021/acs.jmedchem.0c02156 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.603 Å) |
Structure validation
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