7NQ2

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (S)-N4-cyclopropyl-N2-methyl-6-(1-phenylethyl)pyridine-2,4-dicarboxamide

これはPDB形式変換不可エントリーです。

7NQ2 の概要

• エントリーDOI: 10.2210/pdb7nq2/pdb
• 関連するPDBエントリー: 7NPY 7NPZ
• 分子名称: Bromodomain-containing protein 2, ~{N}4-cyclopropyl-~{N}2-methyl-6-[(1~{S})-1-phenylethyl]pyridine-2,4-dicarboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13879.99

構造登録者

Chung, C. (登録日: 2021-02-28, 公開日: 2021-07-21, 最終更新日: 2021-08-25)

• 主引用文献: Harrison, L.A.,Atkinson, S.J.,Bassil, A.,Chung, C.W.,Grandi, P.,Gray, J.R.J.,Levernier, E.,Lewis, A.,Lugo, D.,Messenger, C.,Michon, A.M.,Mitchell, D.J.,Preston, A.,Prinjha, R.K.,Rioja, I.,Seal, J.T.,Taylor, S.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H.; Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.; J.Med.Chem., 64:10742-10771, 2021; PubMed: 34232650; DOI: 10.1021/acs.jmedchem.0c02155

実験手法

X-RAY DIFFRACTION (1.735 Å)