7NPM

X-ray structure of the adduct formed upon reaction of oxaliplatin with human angiogenin

これはPDB形式変換不可エントリーです。

7NPM の概要

• エントリーDOI: 10.2210/pdb7npm/pdb
• 分子名称: Angiogenin, PLATINUM (II) ION, D(-)-TARTARIC ACID, ... (4 entities in total)
• 機能のキーワード: oxaliplatin, cancer, angiogenesis, protein metallation, angiogenin, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14679.11

構造登録者

Ferraro, G.,Merlino, A. (登録日: 2021-02-27, 公開日: 2022-03-23, 最終更新日: 2024-11-13)

主引用文献

Marzo, T.,Ferraro, G.,Cucci, L.M.,Pratesi, A.,Hansson, O.,Satriano, C.,Merlino, A.,La Mendola, D.
Oxaliplatin inhibits angiogenin proliferative and cell migration effects in prostate cancer cells.
J.Inorg.Biochem., 226:111657-111657, 2022

PubMed Abstract: Angiogenin (Ang) is a potent angiogenic protein that is overexpressed in many types of cancer at concentration values correlated to the tumor aggressiveness. Here, by means of an integrated multi-technique approach based on crystallographic, spectrometric and spectroscopic analyses, we demonstrate that the anti-cancer drug oxaliplatin efficiently binds angiogenin. Microscopy cellular studies, carried out on the prostate cancer cell (PC-3) line , show that oxaliplatin inhibits the angiogenin prompting effect on cell proliferation and migration, which are typical features of angiogenesis process. Overall, our findings point to angiogenin as a possible target of oxaliplatin, thus suggesting a potential novel mechanism for the antineoplastic activity of this platinum drug and opening the avenue to novel approaches in the combined anti-cancer anti-angiogenic therapy.

PubMed: 34784565
DOI: 10.1016/j.jinorgbio.2021.111657

実験手法

X-RAY DIFFRACTION (1.86 Å)