7NPK

ALPHA-1 ANTITRYPSIN C232S COMPLEXED WITH CMPD3

Summary for 7NPK

• Entry DOI: 10.2210/pdb7npk/pdb
• Descriptor: Alpha-1-antitrypsin, GLYCEROL, N-((1S,2R)-1-hydroxy-1-(o-tolyl)pentan-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxamide, ... (4 entities in total)
• Functional Keywords: apha1 antitrypsin (c232s), serprin, inhibitor, complex, unknown function
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 46005.09

Authors

Chung, C. (deposition date: 2021-02-27, release date: 2021-04-07, Last modification date: 2024-05-01)

• Primary citation: Liddle, J.,Pearce, A.C.,Arico-Muendel, C.,Belyanskaya, S.,Brewster, A.,Brown, M.,Chung, C.W.,Denis, A.,Dodic, N.,Dossang, A.,Eddershaw, P.,Klimaszewska, D.,Haq, I.,Holmes, D.S.,Jagger, A.,Jakhria, T.,Jigorel, E.,Lind, K.,Messer, J.,Neu, M.,Olszewski, A.,Ronzoni, R.,Rowedder, J.,Rudiger, M.,Skinner, S.,Smith, K.J.,Trottet, L.,Uings, I.,Zhu, Z.,Irving, J.A.,Lomas, D.A.; The development of highly potent and selective small molecule correctors of Z alpha 1 -antitrypsin misfolding.; Bioorg.Med.Chem.Lett., 41:127973-127973, 2021; PubMed: 33753261; DOI: 10.1016/j.bmcl.2021.127973

Experimental method

X-RAY DIFFRACTION (1.83 Å)