7NOY

Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis in complex with substrate 1-hydroxyquinolin-4(1H)-one

7NOY の概要

• エントリーDOI: 10.2210/pdb7noy/pdb
• 分子名称: Uncharacterized protein Rv0560c, S-ADENOSYL-L-HOMOCYSTEINE, 1-oxidanylquinolin-4-one, ... (5 entities in total)
• 機能のキーワード: methyltransferase, hqno-detoxification, sam-dependent, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27035.02

構造登録者

Denkhaus, L.,Sartor, P.,Einsle, O.,Gerhardt, S.,Fetzner, S. (登録日: 2021-02-26, 公開日: 2021-09-22, 最終更新日: 2024-01-31)

• 主引用文献: Sartor, P.,Denkhaus, L.,Gerhardt, S.,Einsle, O.,Fetzner, S.; Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis.; J.Struct.Biol., 213:107794-107794, 2021; PubMed: 34506908; DOI: 10.1016/j.jsb.2021.107794

実験手法

X-RAY DIFFRACTION (1.8 Å)