7NNK

Crystal structure of S116A mutant of hydroxy ketone aldolase (SwHKA) from Sphingomonas wittichii RW1 in complex with hydroxypyruvate

Summary for 7NNK

• Entry DOI: 10.2210/pdb7nnk/pdb
• Related: 6R62
• Descriptor: HpcH/HpaI aldolase, 3-HYDROXYPYRUVIC ACID, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: class ii pyruvate aldolase, metal dependent, aldol reaction, hydroxypyruvate, pyruvate, aldolase, class ii, lyase
• Biological source: Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
• Total number of polymer chains: 2
• Total formula weight: 53689.72

Authors

Justo, I.,Marsden, S.R.,Hanefeld, U.,Bento, I. (deposition date: 2021-02-25, release date: 2022-11-16, Last modification date: 2024-01-31)

• Primary citation: Marsden, S.R.,Wijma, H.J.,Mohr, M.K.F.,Justo, I.,Hagedoorn, P.L.,Laustsen, J.,Jeffries, C.M.,Svergun, D.,Mestrom, L.,McMillan, D.G.G.,Bento, I.,Hanefeld, U.; Substrate Induced Movement of the Metal Cofactor between Active and Resting State.; Angew.Chem.Int.Ed.Engl., 61:e202213338-e202213338, 2022; PubMed: 36214476; DOI: 10.1002/anie.202213338

Experimental method

X-RAY DIFFRACTION (1.8 Å)