7NL7

Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand

7NL7 の概要

• エントリーDOI: 10.2210/pdb7nl7/pdb
• 分子名称: DC-SIGN, CRD domain, CALCIUM ION, 3-Aminopropyl 2-deoxy-2-(4-phenyl-1,2,3-triazol-1-yl)-alpha-D-mannopyranoside, ... (4 entities in total)
• 機能のキーワード: lectin, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18644.68

構造登録者

Jakob, R.P.,Cramer, J.,Lakkaichi, A.,Aliu, B.,Cattaneo, I.,Klein, S.,Jiang, X.,Rabbani, S.,Schwardt, O.,Ernst, B.,Maier, T. (登録日: 2021-02-22, 公開日: 2021-10-27, 最終更新日: 2024-01-31)

• 主引用文献: Cramer, J.,Lakkaichi, A.,Aliu, B.,Jakob, R.P.,Klein, S.,Cattaneo, I.,Jiang, X.,Rabbani, S.,Schwardt, O.,Zimmer, G.,Ciancaglini, M.,Abreu Mota, T.,Maier, T.,Ernst, B.; Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.; J.Am.Chem.Soc., 143:17465-17478, 2021; PubMed: 34652144; DOI: 10.1021/jacs.1c06778

実験手法

X-RAY DIFFRACTION (2.1 Å)