7NIW

Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation)

Summary for 7NIW

• Entry DOI: 10.2210/pdb7niw/pdb
• Related: 7NIU 7NIV
• EMDB information: 12367
• Descriptor: Phosphatidylcholine translocator ABCB4, 4B1 Fab-fragment light chain, 4B1 Fab-fragment heavy chain, ... (6 entities in total)
• Functional Keywords: abcb4, mdr3, nanodisc, lipid transporter, transporter, phosphatidylcholine, protein transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 193737.72

Authors

Nosol, K.,Locher, K.P. (deposition date: 2021-02-14, release date: 2021-08-25)

• Primary citation: Nosol, K.,Bang-Sorensen, R.,Irobalieva, R.N.,Erramilli, S.K.,Stieger, B.,Kossiakoff, A.A.,Locher, K.P.; Structures of ABCB4 provide insight into phosphatidylcholine translocation.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34385322; DOI: 10.1073/pnas.2106702118

Experimental method

ELECTRON MICROSCOPY (3.8 Å)