7NH8

Crystal structure of human carbonic anhydrase II with N-((1-(6-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-4-sulfamoylbenzamide

This is a non-PDB format compatible entry.

Summary for 7NH8

• Entry DOI: 10.2210/pdb7nh8/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, N-((1-(6-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-4-sulfamoylbenzamide, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase ii, inhibitor, sulfonamide, metalloenzyme, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29891.12

Authors

Angeli, A.,Ferraroni, M. (deposition date: 2021-02-10, release date: 2022-02-23, Last modification date: 2024-01-31)

• Primary citation: Pratesi, D.,Sodini, A.,Matassini, C.,Cardona, F.,Angeli, A.,Carta, F.,Ferraroni, M.,Supuran, C.T.,Goti, A.; Synthesis of Azasugar-Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity; Eur.J.Org.Chem., 2021; DOI: 10.1002/ejoc.202100250

Experimental method

X-RAY DIFFRACTION (1.369 Å)