7NG7
Src kinase bound to eCF506 trapped in inactive conformation
Summary for 7NG7
Entry DOI | 10.2210/pdb7ng7/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 1,2-ETHANEDIOL, tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino)piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate, ... (4 entities in total) |
Functional Keywords | src kinase, inhibitor complex, inactive kinase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33329.26 |
Authors | Lietha, D.,Unciti-Broceta, A. (deposition date: 2021-02-08, release date: 2021-09-15, Last modification date: 2024-01-31) |
Primary citation | Temps, C.,Lietha, D.,Webb, E.R.,Li, X.F.,Dawson, J.C.,Muir, M.,Macleod, K.G.,Valero, T.,Munro, A.F.,Contreras-Montoya, R.,Luque-Ortega, J.R.,Fraser, C.,Beetham, H.,Schoenherr, C.,Lopalco, M.,Arends, M.J.,Frame, M.C.,Qian, B.Z.,Brunton, V.G.,Carragher, N.O.,Unciti-Broceta, A. A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability. Cancer Res., 81:5438-5450, 2021 Cited by PubMed: 34417202DOI: 10.1158/0008-5472.CAN-21-0613 PDB entries with the same primary citation |
Experimental method |
Structure validation
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