7NFV

Structure of SARS-CoV-2 Papain-like protease PLpro

This is a non-PDB format compatible entry.

Summary for 7NFV

• Entry DOI: 10.2210/pdb7nfv/pdb
• Descriptor: Papain-like protease nsp3, ZINC ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: papain-like protease sars-cov-2 hydrolase zinc binding protein, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 35994.88

Authors

Srinivasan, V.,Gunther, S.,Reinke, P.,Werner, N.,Falke, S.,Brognaro, H.,Ullah, N.,Andaleeb, H.,Perbandt, M.,Alves Franca, B.,Schwinzer, M.,Wang, M.,Sprenger, J.,Lieske, J.,Ginn, H.,Lane, T.J.,Yefanov, O.,Gelisio, L.,Koua, F.,Saouane, S.,Tolstikova, A.,Groessler, M.,Fleckenstein, H.,Ewert, W.,Trost, F.,Lorenzen, K.,Schubert, R.,Han, H.,Schmidt, C.,Brings, L.,Ehrt, C.,Rarey, M.,Galchenkova, M.,Gevorkov, Y.,Li, C.,Perk, A.,Awel, S.,Hinrichs, W.,Meents, A.,Betzel, C. (deposition date: 2021-02-07, release date: 2021-02-24, Last modification date: 2024-01-31)

• Primary citation: Srinivasan, V.,Brognaro, H.,Prabhu, P.R.,de Souza, E.E.,Gunther, S.,Reinke, P.Y.A.,Lane, T.J.,Ginn, H.,Han, H.,Ewert, W.,Sprenger, J.,Koua, F.H.M.,Falke, S.,Werner, N.,Andaleeb, H.,Ullah, N.,Franca, B.A.,Wang, M.,Barra, A.L.C.,Perbandt, M.,Schwinzer, M.,Schmidt, C.,Brings, L.,Lorenzen, K.,Schubert, R.,Machado, R.R.G.,Candido, E.D.,Oliveira, D.B.L.,Durigon, E.L.,Niebling, S.,Garcia, A.S.,Yefanov, O.,Lieske, J.,Gelisio, L.,Domaracky, M.,Middendorf, P.,Groessler, M.,Trost, F.,Galchenkova, M.,Mashhour, A.R.,Saouane, S.,Hakanpaa, J.,Wolf, M.,Alai, M.G.,Turk, D.,Pearson, A.R.,Chapman, H.N.,Hinrichs, W.,Wrenger, C.,Meents, A.,Betzel, C.; Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.; Commun Biol, 5:805-805, 2022; PubMed: 35953531; DOI: 10.1038/s42003-022-03737-7

Experimental method

X-RAY DIFFRACTION (1.42 Å)