7NEX

Crystal structure of alpha Carbonic anhydrase from Schistosoma mansoni bound to 1-(4-fluorophenyl)-3-(4-sulfamoylph enyl)thiourea

Summary for 7NEX

Entry DOI	10.2210/pdb7nex/pdb
Descriptor	Carbonic anhydrase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	lyase
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	2
Total formula weight	78452.33
Authors	Ferraroni, M.,Angeli, A.,Supuran, C.T. (deposition date: 2021-02-05, release date: 2022-03-02, Last modification date: 2024-01-31)
Primary citation	Angeli, A.,Ferraroni, M.,Da'dara, A.A.,Selleri, S.,Pinteala, M.,Carta, F.,Skelly, P.J.,Supuran, C.T. Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides. J.Med.Chem., 64:10418-10428, 2021 Cited by PubMed: 34232641 DOI: 10.1021/acs.jmedchem.1c00840 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation