7NE3
Human TET2 in complex with favourable DNA substrate.
Summary for 7NE3
Entry DOI | 10.2210/pdb7ne3/pdb |
Related | 4NM6 |
Descriptor | Methylcytosine dioxygenase TET2, DNA (5'-D(*AP*CP*AP*GP*GP*(5CM)P*GP*CP*CP*TP*G)-3'), ZINC ION, ... (8 entities in total) |
Functional Keywords | dna binding, complex, iron dependent dioxygenase, tet2, dna modification, epigenetics, 5-methylcytosine, ion binding, iron binding protein, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 59525.79 |
Authors | Rafalski, D.,Bochtler, M. (deposition date: 2021-02-03, release date: 2022-03-02, Last modification date: 2024-01-31) |
Primary citation | Ravichandran, M.,Rafalski, D.,Davies, C.I.,Ortega-Recalde, O.,Nan, X.,Glanfield, C.R.,Kotter, A.,Misztal, K.,Wang, A.H.,Wojciechowski, M.,Razew, M.,Mayyas, I.M.,Kardailsky, O.,Schwartz, U.,Zembrzycki, K.,Morison, I.M.,Helm, M.,Weichenhan, D.,Jurkowska, R.Z.,Krueger, F.,Plass, C.,Zacharias, M.,Bochtler, M.,Hore, T.A.,Jurkowski, T.P. Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function. Sci Adv, 8:eabm2427-eabm2427, 2022 Cited by PubMed: 36070377DOI: 10.1126/sciadv.abm2427 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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