7NE0

Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin

Summary for 7NE0

Entry DOI	10.2210/pdb7ne0/pdb
Related PRD ID	PRD_900013
Descriptor	Netrin-1, Neogenin, Repulsive Guidance Molecule B, ... (8 entities in total)
Functional Keywords	cell surface receptor signaling, axon guidance, migration, cancer, growth cone, receptor clustering, netrin, neogenin, repulsive guidance molecule, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	115766.75
Authors	Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. (deposition date: 2021-02-02, release date: 2021-03-31, Last modification date: 2024-01-31)
Primary citation	Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.H.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184:2103-, 2021 Cited by PubMed: 33740419 DOI: 10.1016/j.cell.2021.02.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation