7NDO

ER-PRS*(-) (L536S, L372R) in complex with raloxifene

Summary for 7NDO

• Entry DOI: 10.2210/pdb7ndo/pdb
• Descriptor: Estrogen receptor, RALOXIFENE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: human estrogen receptor alpha, hera-lbd, raloxifene, ligand binding domain, er, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 58498.76

Authors

Kriegel, M.,Muller, Y.A. (deposition date: 2021-02-02, release date: 2021-08-25, Last modification date: 2024-01-31)

• Primary citation: Kriegel, M.,Wiederanders, H.J.,Alkhashrom, S.,Eichler, J.,Muller, Y.A.; A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.; Sci Rep, 11:10509-10509, 2021; PubMed: 34006920; DOI: 10.1038/s41598-021-89785-1

Experimental method

X-RAY DIFFRACTION (1.6 Å)