7NDM

Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis with bound substrate 4-hydroxyisoquinolin-1(2H)-one

Summary for 7NDM

Entry DOI	10.2210/pdb7ndm/pdb
Descriptor	Heterocyclic toxin methyltransferase (Rv0560c), S-ADENOSYL-L-HOMOCYSTEINE, 4-oxidanyl-2~{H}-isoquinolin-1-one, ... (6 entities in total)
Functional Keywords	methyltransferase, hqno-detoxification, sam-dependent, 1, 4-dihydroxyisoqunioline, transferase
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	1
Total formula weight	27137.07
Authors	Denkhaus, L.,Sartor, P.,Einsle, O.,Gerhardt, S.,Fetzner, S. (deposition date: 2021-02-02, release date: 2021-09-22, Last modification date: 2024-01-31)
Primary citation	Sartor, P.,Denkhaus, L.,Gerhardt, S.,Einsle, O.,Fetzner, S. Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis. J.Struct.Biol., 213:107794-107794, 2021 Cited by PubMed: 34506908 DOI: 10.1016/j.jsb.2021.107794 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation