7NDG
Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B
Summary for 7NDG
Entry DOI | 10.2210/pdb7ndg/pdb |
EMDB information | 12286 |
Descriptor | Netrin-1, Neogenin, Repulsive Guidance Molecule B (C-terminal region), ... (6 entities in total) |
Functional Keywords | signal transduction, cell surface receptors, neuron regeneration, cell migration, netrin, neogenin, repulsive guidance molecule, complex structure, protein-protein interactions, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 391642.15 |
Authors | Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. (deposition date: 2021-02-01, release date: 2021-03-31, Last modification date: 2021-04-28) |
Primary citation | Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.H.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184:2103-, 2021 Cited by PubMed: 33740419DOI: 10.1016/j.cell.2021.02.045 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (5.98 Å) |
Structure validation
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