7ND1
First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain
Summary for 7ND1
Entry DOI | 10.2210/pdb7nd1/pdb |
Descriptor | E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ZINC ION, ... (4 entities in total) |
Functional Keywords | polycomb repressive complex 1 (prc1), inhibitor, gene regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 25121.32 |
Authors | Cierpicki, T.,Lund, G.,Jaremko, L. (deposition date: 2021-01-29, release date: 2021-06-16, Last modification date: 2024-05-15) |
Primary citation | Shukla, S.,Ying, W.,Gray, F.,Yao, Y.,Simes, M.L.,Zhao, Q.,Miao, H.,Cho, H.J.,Gonzalez-Alonso, P.,Winkler, A.,Lund, G.,Purohit, T.,Kim, E.,Zhang, X.,Ray, J.M.,He, S.,Nikolaidis, C.,Ndoj, J.,Wang, J.,Jaremko, L.,Jaremko, M.,Ryan, R.J.H.,Guzman, M.L.,Grembecka, J.,Cierpicki, T. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat.Chem.Biol., 17:784-793, 2021 Cited by PubMed: 34155404DOI: 10.1038/s41589-021-00815-5 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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