7NCF
Crystal structure of HIPK2 in complex with MU135 (compound 21e)
Summary for 7NCF
Entry DOI | 10.2210/pdb7ncf/pdb |
Descriptor | Homeodomain-interacting protein kinase 2, 3-(4-Tert-butylphenyl)-5-(1H-pyrazol-4-yl)furo[3,2-b]pyridine (3 entities in total) |
Functional Keywords | kinase, hipk2, kinase inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42763.90 |
Authors | Chaikuad, A.,Paruch, K.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-01-28, release date: 2021-03-03, Last modification date: 2024-01-31) |
Primary citation | Nemec, V.,Maier, L.,Berger, B.T.,Chaikuad, A.,Drapela, S.,Soucek, K.,Knapp, S.,Paruch, K. Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur.J.Med.Chem., 215:113299-113299, 2021 Cited by PubMed: 33636538DOI: 10.1016/j.ejmech.2021.113299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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