7NBP

Solution structure of DNA duplex containing a 7,8-dihydro-8-oxo-1,N6-ethenoadenine base modification that induces exclusively A->T transversions in Escherichia coli

Summary for 7NBP

• Entry DOI: 10.2210/pdb7nbp/pdb
• NMR Information: BMRB: 34596
• Descriptor: DNA (5'-D(*GP*TP*AP*CP*(EDA)P*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*AP*GP*TP*AP*C)-3') (2 entities in total)
• Functional Keywords: modified dna, dna
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 5503.67

Authors

Aralov, A.V.,Gubina, N.,Cabrero, C.,Tsvetkov, V.B.,Turaev, A.V.,Fedeles, B.I.,Croy, R.G.,Isaakova, E.A.,Melnik, D.,Dukova, S.,Khrulev, A.A.,Varizhuk, A.M.,Gonzalez, C.,Zatsepin, T.S.,Essigmann, J.M. (deposition date: 2021-01-27, release date: 2022-03-02, Last modification date: 2024-06-19)

• Primary citation: Aralov, A.V.,Gubina, N.,Cabrero, C.,Tsvetkov, V.B.,Turaev, A.V.,Fedeles, B.I.,Croy, R.G.,Isaakova, E.A.,Melnik, D.,Dukova, S.,Ryazantsev, D.Y.,Khrulev, A.A.,Varizhuk, A.M.,Gonzalez, C.,Zatsepin, T.S.,Essigmann, J.M.; 7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli.; Nucleic Acids Res., 50:3056-3069, 2022; PubMed: 35234900; DOI: 10.1093/nar/gkac148

Experimental method

SOLUTION NMR