7NAI

Crystal structure of the TIR domain from human SARM1 in complex with 3AD

Summary for 7NAI

• Entry DOI: 10.2210/pdb7nai/pdb
• Descriptor: Sterile alpha and TIR motif-containing protein 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (3 entities in total)
• Functional Keywords: nadase, axon degeneration, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 34040.37

Authors

Shi, Y.,Ve, T. (deposition date: 2021-06-21, release date: 2022-03-23, Last modification date: 2023-10-18)

• Primary citation: Shi, Y.,Kerry, P.S.,Nanson, J.D.,Bosanac, T.,Sasaki, Y.,Krauss, R.,Saikot, F.K.,Adams, S.E.,Mosaiab, T.,Masic, V.,Mao, X.,Rose, F.,Vasquez, E.,Furrer, M.,Cunnea, K.,Brearley, A.,Gu, W.,Luo, Z.,Brillault, L.,Landsberg, M.J.,DiAntonio, A.,Kobe, B.,Milbrandt, J.,Hughes, R.O.,Ve, T.; Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.; Mol.Cell, 82:1643-, 2022; PubMed: 35334231; DOI: 10.1016/j.molcel.2022.03.007

Experimental method

X-RAY DIFFRACTION (1.74 Å)