7NAE

Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM

7NAE の概要

• エントリーDOI: 10.2210/pdb7nae/pdb
• 分子名称: Dihydrofolate reductase, TRIMETHOPRIM, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: dihydrofolate reductase, oxidoreductase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20137.42

構造登録者

Estrada, A.,Wright, D.,Krucinska, J.,Erlandsen, H. (登録日: 2021-06-21, 公開日: 2022-06-29, 最終更新日: 2023-10-18)

• 主引用文献: Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L.; Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.; Commun Biol, 5:459-459, 2022; PubMed: 35562546; DOI: 10.1038/s42003-022-03384-y

実験手法

X-RAY DIFFRACTION (2.35 Å)