7NAA

Crystal structure of Mycobacterium tuberculosis H37Rv PknF kinase domain

Summary for 7NAA

Entry DOI	10.2210/pdb7naa/pdb
Descriptor	Non-specific serine/threonine protein kinase, (4-{[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino}phenyl)[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone (3 entities in total)
Functional Keywords	pknf, mtb, transferase, structural genomics, psi-biology, protein structure initiative, structural genomics consortium, sgc, antimicrobial protein
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	123419.64
Authors	Oliveira, A.A.,Cabarca, S.,dos Reis, C.V.,Takarada, J.E.,Counago, R.M.,Balan, A.,Structural Genomics Consortium (SGC) (deposition date: 2021-06-21, release date: 2021-08-04, Last modification date: 2023-10-18)
Primary citation	Cabarca, S.,Frazao de Souza, M.,Albert de Oliveira, A.,Vignoli Muniz, G.S.,Lamy, M.T.,Vinicius Dos Reis, C.,Takarada, J.,Effer, B.,Souza, L.S.,Iriarte de la Torre, L.,Counago, R.,Pinto Oliveira, C.L.,Balan, A. Structure of the Mycobacterium tuberculosis c PknF and conformational changes induced in forkhead-associated regulatory domains. Curr Res Struct Biol, 3:165-178, 2021 Cited by PubMed: 34382010 DOI: 10.1016/j.crstbi.2021.07.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation