7NAA

Crystal structure of Mycobacterium tuberculosis H37Rv PknF kinase domain

7NAA の概要

• エントリーDOI: 10.2210/pdb7naa/pdb
• 分子名称: Non-specific serine/threonine protein kinase, (4-{[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino}phenyl)[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone (3 entities in total)
• 機能のキーワード: pknf, mtb, transferase, structural genomics, psi-biology, protein structure initiative, structural genomics consortium, sgc, antimicrobial protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 123419.64

構造登録者

Oliveira, A.A.,Cabarca, S.,dos Reis, C.V.,Takarada, J.E.,Counago, R.M.,Balan, A.,Structural Genomics Consortium (SGC) (登録日: 2021-06-21, 公開日: 2021-08-04, 最終更新日: 2023-10-18)

• 主引用文献: Cabarca, S.,Frazao de Souza, M.,Albert de Oliveira, A.,Vignoli Muniz, G.S.,Lamy, M.T.,Vinicius Dos Reis, C.,Takarada, J.,Effer, B.,Souza, L.S.,Iriarte de la Torre, L.,Counago, R.,Pinto Oliveira, C.L.,Balan, A.; Structure of the Mycobacterium tuberculosis c PknF and conformational changes induced in forkhead-associated regulatory domains.; Curr Res Struct Biol, 3:165-178, 2021; PubMed: 34382010; DOI: 10.1016/j.crstbi.2021.07.001

実験手法

X-RAY DIFFRACTION (2.75 Å)