7NA7

Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist

7NA7 の概要

• エントリーDOI: 10.2210/pdb7na7/pdb
• EMDBエントリー: 24267
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: gpcr, appetite, energy homeostasis, reward signaling, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 155593.77

構造登録者

Liu, H.,Sun, D.,Sun, J.,Zhang, C. (登録日: 2021-06-20, 公開日: 2021-12-15)

• 主引用文献: Liu, H.,Sun, D.,Myasnikov, A.,Damian, M.,Baneres, J.L.,Sun, J.,Zhang, C.; Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren; Nat Commun, 12:6410-, 2021; DOI: 10.1038/s41467-021-26735-5

実験手法

ELECTRON MICROSCOPY (2.7 Å)