7NA2

HDM2 in complex with compound 56

7NA2 の概要

• エントリーDOI: 10.2210/pdb7na2/pdb
• 分子名称: Isoform 11 of E3 ubiquitin-protein ligase Mdm2, 3-[4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-{[(1r,4R)-4-methylcyclohexyl]methyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one (3 entities in total)
• 機能のキーワード: p53, drug design, protein-protein interactions, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26284.91

構造登録者

Scapin, G. (登録日: 2021-06-19, 公開日: 2021-11-10, 最終更新日: 2024-05-22)

• 主引用文献: Reutershan, M.H.,Machacek, M.R.,Altman, M.D.,Bogen, S.,Cai, M.,Cammarano, C.,Chen, D.,Christopher, M.,Cryan, J.,Daublain, P.,Fradera, X.,Geda, P.,Goldenblatt, P.,Hill, A.D.,Kemper, R.A.,Kutilek, V.,Li, C.,Martinez, M.,McCoy, M.,Nair, L.,Pan, W.,Thompson, C.F.,Scapin, G.,Shizuka, M.,Spatz, M.L.,Steinhuebel, D.,Sun, B.,Voss, M.E.,Wang, X.,Yang, L.,Yeh, T.C.,Dussault, I.,Marshall, C.G.,Trotter, B.W.; Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.; J.Med.Chem., 64:16213-16241, 2021; PubMed: 34714078; DOI: 10.1021/acs.jmedchem.1c01524

実験手法

X-RAY DIFFRACTION (1.86 Å)