7N9G

Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib

7N9G の概要

• エントリーDOI: 10.2210/pdb7n9g/pdb
• 分子名称: Tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, ... (5 entities in total)
• 機能のキーワード: abl kinase, kinase allosteric regulation, drug resistance, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 97516.01

構造登録者

Miller, D.J.,Xie, T. (登録日: 2021-06-17, 公開日: 2022-04-27, 最終更新日: 2023-10-18)

• 主引用文献: Xie, T.,Saleh, T.,Rossi, P.,Miller, D.,Kalodimos, C.G.; Imatinib can act as an Allosteric Activator of Abl Kinase.; J.Mol.Biol., 434:167349-167349, 2022; PubMed: 34774565; DOI: 10.1016/j.jmb.2021.167349

実験手法

X-RAY DIFFRACTION (2.2 Å)