7N7N

Crystal Structure of PI5P4KIIAlpha complex with Volasertib

7N7N の概要

• エントリーDOI: 10.2210/pdb7n7n/pdb
• 分子名称: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44021.70

構造登録者

Chen, S.,Ha, Y. (登録日: 2021-06-10, 公開日: 2021-06-30, 最終更新日: 2023-10-18)

• 主引用文献: Chen, S.,Chandra Tjin, C.,Gao, X.,Xue, Y.,Jiao, H.,Zhang, R.,Wu, M.,He, Z.,Ellman, J.,Ha, Y.; Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34001596; DOI: 10.1073/pnas.2002486118

実験手法

X-RAY DIFFRACTION (2.3 Å)