7N1J
Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder
Summary for 7N1J
Entry DOI | 10.2210/pdb7n1j/pdb |
Related | 7N1K |
Descriptor | Fibroblast growth factor receptor 4, Binder (2 entities in total) |
Functional Keywords | receptor tyrosine kinase, complex, binder, membrane protein, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 43615.39 |
Authors | Park, J.S.,Lee, S. (deposition date: 2021-05-27, release date: 2022-04-06, Last modification date: 2023-10-18) |
Primary citation | Cao, L.,Coventry, B.,Goreshnik, I.,Huang, B.,Sheffler, W.,Park, J.S.,Jude, K.M.,Markovic, I.,Kadam, R.U.,Verschueren, K.H.G.,Verstraete, K.,Walsh, S.T.R.,Bennett, N.,Phal, A.,Yang, A.,Kozodoy, L.,DeWitt, M.,Picton, L.,Miller, L.,Strauch, E.M.,DeBouver, N.D.,Pires, A.,Bera, A.K.,Halabiya, S.,Hammerson, B.,Yang, W.,Bernard, S.,Stewart, L.,Wilson, I.A.,Ruohola-Baker, H.,Schlessinger, J.,Lee, S.,Savvides, S.N.,Garcia, K.C.,Baker, D. Design of protein-binding proteins from the target structure alone. Nature, 605:551-560, 2022 Cited by PubMed: 35332283DOI: 10.1038/s41586-022-04654-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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