7N12
Crystal structure of the M. abscessus LeuRS editing domain in complex with epetraborole-AMP adduct
7N12 の概要
エントリーDOI | 10.2210/pdb7n12/pdb |
分子名称 | Leucine--tRNA ligase, [(1S,5R,6R,7'S,8R)-7'-(aminomethyl)-6-(6-aminopurin-9-yl)-2'-(3-oxidanylpropoxy)spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-8-yl]methyl dihydrogen phosphate, SULFATE ION, ... (4 entities in total) |
機能のキーワード | oxaborole, inhibitor, complex, antibiotic, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
由来する生物種 | Mycobacteroides abscessus |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 43275.13 |
構造登録者 | |
主引用文献 | Sullivan, J.R.,Lupien, A.,Kalthoff, E.,Hamela, C.,Taylor, L.,Munro, K.A.,Schmeing, T.M.,Kremer, L.,Behr, M.A. Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline. Plos Pathog., 17:e1009965-e1009965, 2021 Cited by PubMed: 34637487DOI: 10.1371/journal.ppat.1009965 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
構造検証レポート
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